Reep6^tm1Asw
Targeted Allele Detail

Summary

• Symbol: Reep6^tm1Asw
• Name: receptor accessory protein 6; targeted mutation 1, Anand Swaroop
• MGI ID: MGI:6116691
• Gene: Reep6 Location: Chr10:80165831-80172275 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Reep6^tm1Asw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242841
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination was used to replace most of the coding region (exon 2 to exon 4) with a beta-galactosidase reporter and a neomycin selection cassette. Western blot confirmed absence of protein in homozygotes. (J:242841)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Reep6 Mutation: 20 strains or lines available

References

• Original: J:242841 Veleri S, et al., REEP6 mediates trafficking of a subset of Clathrin-coated vesicles and is critical for rod photoreceptor function and survival. Hum Mol Genet. 2017 Jun 15;26(12):2218-2230
• All: 2 reference(s)