Hprt1^{tm1(Trm1)Jicn}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(Trm1)Jicn}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Jim C Norman
• MGI ID: MGI:6116690
• Synonyms: 2+tRNAi^Met
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(Trm1)Jicn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252666
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Hprt1^{tm1(Trm1)Jicn} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trm1 (MGI:1890640)

• Mutation details: Two copies of the murine Trm1 gene (tRNA78), including 140 bp of flanking sequence, were targeted into the HPRT locus. (J:252666)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:252666 Clarke CJ, et al., The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis. Curr Biol. 2016 Mar 21;26(6):755-65
• All: 2 reference(s)