Rorb^tm1.1Gld
Targeted Allele Detail

Summary

• Symbol: Rorb^tm1.1Gld
• Name: RAR-related orphan receptor beta; targeted mutation 1.1, Martyn Goulding
• MGI ID: MGI:6116464
• Synonyms: Rorbeta^fl
• Gene: Rorb Location: Chr19:18907969-19088560 bp, - strand Genetic Position: Chr19, 13.28 cM
• Alliance: Rorb^tm1.1Gld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256122
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted on both 5' and 3; of exon 2, which encodes the first zinc finger of the binding domain of the encoded protein. An adjacent frt-flanked neomycin selection cassette was removed by FLP1-mediated recombination. (J:256122)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rorb Mutation: 39 strains or lines available

References

• Original: J:256122 Koch SC, et al., RORbeta Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait. Neuron. 2017 Dec 20;96(6):1419-1431.e5
• All: 2 reference(s)