Nova2^tm2.1Rbd
Targeted Allele Detail

Summary

• Symbol: Nova2^tm2.1Rbd
• Name: NOVA alternative splicing regulator 2; targeted mutation 2.1, Robert B Darnell
• MGI ID: MGI:6116394
• Gene: Nova2 Location: Chr7:18659813-18699244 bp, + strand Genetic Position: Chr7, 9.41 cM
• Alliance: Nova2^tm2.1Rbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234107
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An IRES-Cre-FRT-Neo-FRT targeting cassette was inserted into the Nova2 locus upstream of the initiator ATG in the first known coding exon of the gene. The neomycin cassette was excised by Flp-mediated recombination. No information on the expression of Cre was presented. No endogenous protein was expressed. (J:234107)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nova2 Mutation: 12 strains or lines available

References

• Original: J:234107 Saito Y, et al., NOVA2-mediated RNA regulation is required for axonal pathfinding during development. Elife. 2016;5:e14371
• All: 1 reference(s)