Sox3^em1(Sox2)Pqt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sox3^em1(Sox2)Pqt
• Name: SRY (sex determining region Y)-box 3; endonuclease-mediated mutation 1, Paul Q Thomas
• MGI ID: MGI:6116390
• Synonyms: Sox3^Sox2KI
• Gene: Sox3 Location: ChrX:59934972-59937036 bp, - strand Genetic Position: ChrX, 33.66 cM, cytoband A7.3-B
• Alliance: Sox3^em1(Sox2)Pqt page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Sox3^em1(Sox2)Pqt expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Sox2

• Mutation details: The open reading frame of the gene was replaced with the Sox2 open reading frame. RT-PCR confirmed elevated expression of Sox2 in hemizygous embryos. (J:246645)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox3 Mutation: 7 strains or lines available

References

• Original: J:246645 Adikusuma F, et al., Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes. Genetics. 2017 Jul;206(3):1495-1503
• All: 1 reference(s)