Grn^tm1.1Pvd
Targeted Allele Detail

Summary

• Symbol: Grn^tm1.1Pvd
• Name: granulin; targeted mutation 1.1, Philip Van Damme
• MGI ID: MGI:6116274
• Synonyms: mGRNflox
• Gene: Grn Location: Chr11:102321333-102327635 bp, + strand Genetic Position: Chr11, 66.29 cM
• Alliance: Grn^tm1.1Pvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243041
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked selection cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 8. Flp-mediated recombination removed the selection cassette and left exons 2 through 8 floxed. (J:243041)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grn Mutation: 51 strains or lines available

References

• Original: J:243041 Beel S, et al., Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo. Hum Mol Genet. 2017 Aug 1;26(15):2850-2863
• All: 1 reference(s)