Wnt7a^tm1.2Tesp
Targeted Allele Detail

Summary

• Symbol: Wnt7a^tm1.2Tesp
• Name: wingless-type MMTV integration site family, member 7A; targeted mutation 1.2, Thomas E Spencer
• MGI ID: MGI:6116258
• Synonyms: Wnt7a^delta
• Gene: Wnt7a Location: Chr6:91340963-91388335 bp, - strand Genetic Position: Chr6, 40.45 cM
• Alliance: Wnt7a^tm1.2Tesp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256044
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination remvoed the selection cassette and cre-mediated recombination removed exon 2. (J:256044)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt7a Mutation: 26 strains or lines available

References

• Original: J:256044 Cho C, et al., Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron. 2017 Aug 30;95(5):1056-1073.e5
• All: 1 reference(s)