Drd2^tm4.1Ebo
Targeted Allele Detail

Summary

• Symbol: Drd2^tm4.1Ebo
• Name: dopamine receptor D2; targeted mutation 4.1, Emiliana Borrelli
• MGI ID: MGI:6116236
• Synonyms: D2S^-
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^tm4.1Ebo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256169
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 through 7 were replaced with a cDNA for exons 5, 6 and 7 corresponding to the D2L isoform. Cre-mediated removed a floxed neomycin resistance cassette inserted downstream of the cDNA. (J:256169)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:256169 Radl D, et al., Each individual isoform of the dopamine D2 receptor protects from lactotroph hyperplasia. Mol Endocrinol. 2013 Jun;27(6):953-65
• All: 3 reference(s)