Slc2a3^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Slc2a3^{tm1c(KOMP)Wtsi}
• Name: solute carrier family 2 (facilitated glucose transporter), member 3; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6116230
• Synonyms: GLUT3 floxed
• Gene: Slc2a3 Location: Chr6:122704768-122778599 bp, - strand Genetic Position: Chr6, 57.82 cM
• Alliance: Slc2a3^{tm1c(KOMP)Wtsi} page
• IMPC: Slc2a3 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256581
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Pgk_P cassette was inserted at position 122712097 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 122713050. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:256581)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc2a3 Mutation: 45 strains or lines available

References

• Original: J:256581 Fidler TP, et al., Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1628-1639
• All: 10 reference(s)