Inppl1^tm2.1Ssch
Targeted Allele Detail

Summary

• Symbol: Inppl1^tm2.1Ssch
• Name: inositol polyphosphate phosphatase-like 1; targeted mutation 2.1, Stephane Schurmans
• MGI ID: MGI:6115850
• Synonyms: Ship2^flox(18+19)
• Gene: Inppl1 Location: Chr7:101471839-101487419 bp, - strand Genetic Position: Chr7, 54.67 cM, cytoband F1
• Alliance: Inppl1^tm2.1Ssch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256569
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 18. An FRT-flanked neomycin resistance with a 3' loxP site was inserted downsteam of exon 19. Flp-mediated recombination removed the selection cassette and left exons 18 and 19 floxed. (J:256569)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inppl1 Mutation: 43 strains or lines available

References

• Original: J:256569 Dubois E, et al., Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse. Cell Signal. 2012 Nov;24(11):1971-80
• All: 5 reference(s)