Dapk1^tm3.1Ylu
Targeted Allele Detail

Summary

• Symbol: Dapk1^tm3.1Ylu
• Name: death associated protein kinase 1; targeted mutation 3.1, Youming Lu
• MGI ID: MGI:6115619
• Synonyms: DAPK1^DDloxP
• Gene: Dapk1 Location: Chr13:60749761-60911005 bp, + strand Genetic Position: Chr13, 32.53 cM
• Alliance: Dapk1^tm3.1Ylu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236450
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Undefined
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 27. A loxP site was inserted upstream of exon 26, which encodes the death domain. Flp-mediated recombination removed the selection cassette. (J:236450)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dapk1 Mutation: 125 strains or lines available

References

• Original: J:236450 Shu S, et al., Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1. J Neurosci. 2016 Oct 19;36(42):10843-10852
• All: 2 reference(s)