Irf2bp2^tm1.1Afrs
Targeted Allele Detail

Summary

• Symbol: Irf2bp2^tm1.1Afrs
• Name: interferon regulatory factor 2 binding protein 2; targeted mutation 1.1, Alexandre F R Stewart
• MGI ID: MGI:6115596
• Synonyms: IRF2BP2^flox
• Gene: Irf2bp2 Location: Chr8:127315035-127320725 bp, - strand Genetic Position: Chr8, 74.57 cM
• Alliance: Irf2bp2^tm1.1Afrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249107
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted upstream of the promoter and downstream of the 3'UTR. A PGKneo selection cassette flanked by FRT sites after the first loxP site. Flp-mediated recombination removed the selection cassette. (J:249107)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf2bp2 Mutation: 15 strains or lines available

References

• Original: J:249107 Chen HH, et al., IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis. Circ Res. 2015 Sep 25;117(8):671-83
• All: 5 reference(s)