Rnf8^tm1.1Azbi
Targeted Allele Detail

Summary

• Symbol: Rnf8^tm1.1Azbi
• Name: ring finger protein 8; targeted mutation 1.1, Azad Bonni
• MGI ID: MGI:6115595
• Synonyms: RNF8^loxP
• Gene: Rnf8 Location: Chr17:29833763-29860638 bp, + strand Genetic Position: Chr17, 15.45 cM
• Alliance: Rnf8^tm1.1Azbi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256244
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 7. Flp-mediated recombination removed the selection cassette and left exons 6 and 7 floxed. (J:256244)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf8 Mutation: 18 strains or lines available

References

• Original: J:256244 Valnegri P, et al., RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain. Nat Commun. 2017 Nov 2;8(1):1271
• All: 1 reference(s)