Vcl^tm2.1Whz
Targeted Allele Detail

Summary

• Symbol: Vcl^tm2.1Whz
• Name: vinculin; targeted mutation 2.1, Wolfgang H Ziegler
• MGI ID: MGI:6115589
• Gene: Vcl Location: Chr14:20979466-21083744 bp, + strand Genetic Position: Chr14, 11.53 cM
• Alliance: Vcl^tm2.1Whz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256217
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 22. An FRT-flanked neomycin resistance cassette was inserted downsteam of exon 22. Flp-mediated recombination removed the selection cassette and left exon 22 floxed. (J:256217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vcl Mutation: 49 strains or lines available

References

• Original: J:256217 Rubsam M, et al., E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning. Nat Commun. 2017 Nov 1;8(1):1250
• All: 1 reference(s)