Rbm38^{tm1d(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Rbm38^{tm1d(KOMP)Mbp}
• Name: RNA binding motif protein 38; targeted mutation 1d, Mouse Biology Program, UC Davis
• MGI ID: MGI:6115587
• Synonyms: Rbm38^-
• Gene: Rbm38 Location: Chr2:172863722-172876527 bp, + strand Genetic Position: Chr2, 95.67 cM
• Alliance: Rbm38^{tm1d(KOMP)Mbp} page
• IMPC: Rbm38 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256183
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 172864352 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 172865432. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). (J:256183)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbm38 Mutation: 9 strains or lines available

References

• Original: J:256183 van den Hoogenhof MMG, et al., The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice. PLoS One. 2017;12(8):e0184093
• All: 1 reference(s)