Arid3a^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Arid3a^{tm1c(KOMP)Wtsi}
• Name: AT-rich interaction domain 3A; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6115543
• Synonyms: Arid3a^fl
• Gene: Arid3a Location: Chr10:79762877-79790852 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Arid3a^{tm1c(KOMP)Wtsi} page
• IMPC: Arid3a gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255997
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 79781829 of Chromosome 10 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 79782681. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:255997)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arid3a Mutation: 20 strains or lines available

References

• Original: J:255997 Habir K, et al., A Role for the Transcription Factor Arid3a in Mouse B2 Lymphocyte Expansion and Peritoneal B1a Generation. Front Immunol. 2017;8:1387
• All: 3 reference(s)