Cd274^tm1Pfal
Targeted Allele Detail

Summary

• Symbol: Cd274^tm1Pfal
• Name: CD274 antigen; targeted mutation 1, Padraic Fallon
• MGI ID: MGI:6115470
• Synonyms: PD-L1^fl
• Gene: Cd274 Location: Chr19:29344855-29365495 bp, + strand Genetic Position: Chr19, 23.88 cM, cytoband C2
• Alliance: Cd274^tm1Pfal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. (J:244473)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd274 Mutation: 72 strains or lines available

References

• Original: J:244473 Schwartz C, et al., ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control. J Exp Med. 2017 Sep 04;214(9):2507-2521
• All: 6 reference(s)