Pik3ca^tm4Bvan
Targeted Allele Detail

Summary

• Symbol: Pik3ca^tm4Bvan
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 4, Bart Vanhaesebroeck
• MGI ID: MGI:6115348
• Synonyms: Pik3ca^H1047R+neo
• Gene: Pik3ca Location: Chr3:32451203-32520256 bp, + strand Genetic Position: Chr3, 15.7 cM, cytoband B
• Alliance: Pik3ca^tm4Bvan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255747
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Undefined
• Mutation details: Gene targeted produced the nucleotide substitution CAT to CGT and resulted in the amino acid substitution of arginine for histidine at position 1047 (H1047R). An FRT-flanked neomycin resistance cassette was inserted into exons 19 and 20. (J:255747)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3ca Mutation: 62 strains or lines available

References

• Original: J:255747 Berenjeno IM, et al., Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling. Nat Commun. 2017 Nov 24;8(1):1773
• All: 1 reference(s)