Cacna1b^tm4.1Dili
Targeted Allele Detail

Summary

• Symbol: Cacna1b^tm4.1Dili
• Name: calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 4.1, Diane Lipscombe
• MGI ID: MGI:6114725
• Synonyms: delta 18a
• Gene: Cacna1b Location: Chr2:24493899-24653164 bp, - strand Genetic Position: Chr2, 16.58 cM, cytoband A2
• Alliance: Cacna1b^tm4.1Dili page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255284
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: Exon choice was restricted by replacing exons 18, 18a and 19 with a neomycin selection cassette followed by a fusion of exons 18 and 19. This allele expresses transcripts that never include alternatively spliced exon 18a (J:255284)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1b Mutation: 104 strains or lines available

References

• Original: J:255284 Allen SE, et al., Cell-Specific RNA Binding Protein Rbfox2 Regulates CaV2.2 mRNA Exon Composition and CaV2.2 Current Size. eNeuro. 2017 Sep-Oct;4(5):ENEURO.0332-16.2017
• All: 2 reference(s)