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Slc1a5tm1Tac
Targeted Allele Detail
Nomenclature
Symbol: Slc1a5tm1Tac
Name: solute carrier family 1 (neutral amino acid transporter), member 5; targeted mutation 1, Taconic
MGI ID: MGI:6113803
Gene: Slc1a5  Location: Chr7:16781345-16798274 bp, + strand  Genetic Position: Chr7, 9.15 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:254980
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ-neomycin resistance cassette replaced exons 2 through 4. RT-PCR confirmed the absence of transcript expression. (J:254980)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc1a5 Mutation:  12 strains or lines available
References
Original:  J:254980 Nakaya M, et al., Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity. 2014 May 15;40(5):692-705
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory