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Targeted Allele Detail
Symbol: Penktm1.1(cre)Gsche
Name: preproenkephalin; targeted mutation 1.1, Gregory Scherrer
MGI ID: MGI:6113637
Synonyms: Penkcre
Gene: Penk  Location: Chr4:4133531-4138819 bp, - strand  Genetic Position: Chr4, 2.31 cM
Germline Transmission:  Earliest citation of germline transmission: J:253245
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac or C57BL/6J
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Mutation detailsThe targeting vector was constructed using recombineering techniques. An 8,528 bp genomic DNA fragment containing the last exon of the mouse Penk gene was retrieved from BAC clone RP23-RP23- 365K8 to a vector containing the DT gene. A cassette of IRES-Cre frt-PGKNeo-frt was inserted between stop codon TGA and 3' UTR. The neo cassette was removed by breeding germline chimeras with FLP1 expressing homozygous females. (J:253245)
 Tissue activity of this recombinase allele
Driver: Penk     Summary of all recombinase alleles driven by Penk. Comparative matrix view of recombinase activities

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Penk Mutation:  5 strains or lines available
"The targeting vector was electroporated into F1 hybrid of 129S6 x C57BL/6J ES cells derived by Janelia Transgenic Facility." (J:253245)
Original:  J:253245 Francois A, et al., A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins. Neuron. 2017 Feb 22;93(4):822-839.e6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory