Cd274^tm1Maike
Targeted Allele Detail

Summary

• Symbol: Cd274^tm1Maike
• Name: CD274 antigen; targeted mutation 1, Maike Schmidt
• MGI ID: MGI:6113522
• Synonyms: PD-L1 ko
• Gene: Cd274 Location: Chr19:29344855-29365495 bp, + strand Genetic Position: Chr19, 23.88 cM, cytoband C2
• Alliance: Cd274^tm1Maike page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244274
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 (containing the ATG translation start site and the IgV domain) were replaced with a neomycin resistance gene cassette. (J:244274)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd274 Mutation: 36 strains or lines available

References

• Original: J:244274 Lau J, et al., Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice. Nat Commun. 2017 Feb 21;8:14572
• All: 2 reference(s)