Ptpro^tm1.1Ael
Targeted Allele Detail

Summary

• Symbol: Ptpro^tm1.1Ael
• Name: protein tyrosine phosphatase receptor type O; targeted mutation 1.1, Ari Elson
• MGI ID: MGI:6112577
• Synonyms: ROKO
• Gene: Ptpro Location: Chr6:137229317-137440231 bp, + strand Genetic Position: Chr6, 66.75 cM
• Alliance: Ptpro^tm1.1Ael page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243384
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: The P2 distal promoter that regulates expression of isoform t was deleted. Expression via the proximal P1 promoter of the gene is unaffected, hence these mice produce the mRNA and protein of the distinct GLEPP-1. Cre-mediated recombination removed the neomycin resistance cassette inserted upstream of exon S1. (J:243384)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpro Mutation: 121 strains or lines available

References

• Original: J:243384 Wakim J, et al., The PTPROt tyrosine phosphatase functions as an obligate haploinsufficient tumor suppressor in vivo in B-cell chronic lymphocytic leukemia. Oncogene. 2017 Jun 29;36(26):3686-3694
• All: 1 reference(s)