Kctd13tm1.1(KOMP)Vlcg
Targeted Allele Detail
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Symbol: |
Kctd13tm1.1(KOMP)Vlcg |
Name: |
potassium channel tetramerisation domain containing 13; targeted mutation 1.1, Velocigene |
MGI ID: |
MGI:6111982 |
Synonyms: |
Kctd13 KO |
Gene: |
Kctd13 Location: Chr7:126528051-126544781 bp, + strand Genetic Position: Chr7, 69.25 cM
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Alliance: |
Kctd13tm1.1(KOMP)Vlcg page
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IMPC: |
Kctd13 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:250125
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Parent Cell Line: |
VGB6 (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Project Collection: |
KOMP-Regeneron
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A Velocigene cassette ZEN-Ub1 replaced a genomic region of size 16081bp between positions 134072572-134088652 of Chromosome 7 (Genome Build37). The hUBCpro-neo-p(A) cassette was removed via cre-mediated recombination. Western blot analysis confirmed complete loss of protein expression in various brain regions (hippocampus, cortex, cerebellum and midbrain) from homozygous mutant mice and a ~50% reduction in heterozygotes.
(J:250125)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kctd13 Mutation: |
13 strains or lines available
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Original: |
J:250125 Escamilla CO, et al., Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017 Nov 9;551(7679):227-231 |
All: |
1 reference(s) |
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