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Axin2em1Fstl
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Axin2em1Fstl
Name: axin 2; endonuclease-mediated mutation 1, Frank Staal
MGI ID: MGI:6111808
Synonyms: Axin2-TQ
Gene: Axin2  Location: Chr11:108920349-108950783 bp, + strand  Genetic Position: Chr11, 71.83 cM
Mutation
origin
Strain of Origin:  (C57BL/6J x CBA/J)F1 x C57BL/6JIcoCrlLumc
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCRISPR/Cas9 mediated mutatgenesis was used to replace most of exon 2 (including the start codon) with an mTurquoise2 (green fluorescent protein in far blue) coding sequence and a loxP-flanked neomycin resistance (neo) cassette. Reporter expression is under the control of endogenous gene promoter. (J:252680)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Axin2 Mutation:  26 strains or lines available
References
Original:  J:252680 de Roo JJD, et al., Axin2-mTurquoise2: A novel reporter mouse model for the detection of canonical Wnt signalling. Genesis. 2017 Oct;55(10)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory