Rr43^em1Axvi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr43^em1Axvi
• Name: regulatory region 43; endonuclease-mediated mutation 1, Axel Visel
• MGI ID: MGI:6111734
• Synonyms: deltahs122
• Gene: Rr43 Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Rr43^em1Axvi page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: CRISPR targeting deleted 1744 bp (chrX:93,300,959-93,302,702; mm10) and insertion a "TC" to generate an AatII restriction site in place of the Arx enhancer. (J:254531)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rr43 Mutation: 2 strains or lines available

References

• Original: J:254531 Dickel DE, et al., Ultraconserved Enhancers Are Required for Normal Development. Cell. 2018 Jan 25;172(3):491-499.e15
• All: 1 reference(s)