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Arpc4tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Arpc4tm1c(EUCOMM)Wtsi
Name: actin related protein 2/3 complex, subunit 4; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:6111539
Synonyms: Arpc4f
Gene: Arpc4  Location: Chr6:113378115-113390448 bp, + strand  Genetic Position: Chr6, 52.76 cM
Mutation
origin
Mutant Cell Line:  EPD0058_1_A11
Germline Transmission:  Earliest citation of germline transmission: J:253986
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_gt0
 
Mutation detailsThe L1L2_gt0 cassette was inserted at position 113380281 of Chromosome 6 upstream of the critical exon (exon 2) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 2 at position 113381122. Exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving exon 2 flanked by loxP sites. (J:253986)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arpc4 Mutation:  14 strains or lines available
References
Original:  J:253986 van der Kammen R, et al., Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2. Development. 2017 Dec 15;144(24):4588-4603
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory