Phox2a^{tm1(Asci2*)Jbr}
Targeted Allele Detail

Summary

• Symbol: Phox2a^{tm1(Asci2*)Jbr}
• Name: paired-like homeobox 2a; targeted mutation 1, Jean-Francois Brunet
• MGI ID: MGI:6111410
• Synonyms: Phox2a^ASIC2a
• Gene: Phox2a Location: Chr7:101467520-101471933 bp, + strand Genetic Position: Chr7, 54.66 cM
• Alliance: Phox2a^{tm1(Asci2*)Jbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249229
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A cDNA for rat Asic2 harboring a G430F mutation was inserted between the first and second exon of the gene, preceded by a floxed EGFP-Neo-STOP-IRES cassette, itself preceded by a splice acceptor site. Upon Cre-mediated recombination the mutant rat Asic2, encoding a toxic allele of the sodium channel, is transcribed from the endogenous promoter. (J:249229)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phox2a Mutation: 10 strains or lines available

References

• Original: J:249229 Espinosa-Medina I, et al., Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors. Science. 2014 Jul 4;345(6192):87-90
• All: 2 reference(s)