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Myo9atm1.2Bah
Targeted Allele Detail
Nomenclature
Symbol: Myo9atm1.2Bah
Name: myosin IXa; targeted mutation 1.2, Martin Bahler
MGI ID: MGI:6111331
Gene: Myo9a  Location: Chr9:59750896-59928866 bp, + strand  Genetic Position: Chr9, 32.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:251454
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCre-mediated recombination of loxP sites surrounding exon 2, which includes part of the 5' UTR and codes for the N-terminal 280 of 2542 amino acids of the protein, resulted in the removal of this exon in the germline. Expression of the encoded protein was shown to be abolished by Western blot analysis of protein extracts derived from homozygous mutant mice. (J:251454)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myo9a Mutation:  18 strains or lines available
References
Original:  J:251454 Abouhamed M, et al., Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus. Mol Biol Cell. 2009 Dec;20(24):5074-85
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory