Brs3^tm1.1Rei
Targeted Allele Detail

Summary

• Symbol: Brs3^tm1.1Rei
• Name: bombesin-like receptor 3; targeted mutation 1.1, Marc L Reitman
• MGI ID: MGI:6109970
• Synonyms: Brs3^fl
• Gene: Brs3 Location: ChrX:56088434-56094118 bp, + strand Genetic Position: ChrX, 30.78 cM, cytoband A7.1-A7.2
• Alliance: Brs3^tm1.1Rei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253437
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains a loxP-flanked PGK-Neo selection cassette inserted downstream of exon 2 of the targeted gene, and another loxP site inserted upstream of exon 2. Cre-mediated recombination removed the downstream floxed neo cassette and left exon 2 floxed. (J:253437)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brs3 Mutation: 14 strains or lines available

References

• Original: J:253437 Xiao C, et al., Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism. Mol Metab. 2017 Nov;6(11):1540-1550
• All: 2 reference(s)