Dpp4^tm1Ddr
Targeted Allele Detail

Summary

• Symbol: Dpp4^tm1Ddr
• Name: dipeptidylpeptidase 4; targeted mutation 1, DJ Drucker
• MGI ID: MGI:6109965
• Synonyms: Flox Dpp4
• Gene: Dpp4 Location: Chr2:62160417-62242575 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C2-D
• Alliance: Dpp4^tm1Ddr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251869
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• The LoxP sites span the catalytic serine in exon 22 of the gene. (J:251869)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpp4 Mutation: 73 strains or lines available

References

• Original: J:251869 Mulvihill EE, et al., Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis. Cell Metab. 2017 Jan 10;25(1):152-165
• All: 4 reference(s)