Ephx3^tm1.2Dcz
Targeted Allele Detail

Summary

• Symbol: Ephx3^tm1.2Dcz
• Name: epoxide hydrolase 3; targeted mutation 1.2, Darryl C Zeldin
• MGI ID: MGI:6108326
• Gene: Ephx3 Location: Chr17:32402742-32408444 bp, - strand Genetic Position: Chr17, 17.39 cM
• Alliance: Ephx3^tm1.2Dcz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246524
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 1-4. qPCR analysis found low to undetectable levels of mRNA in various tissues from homozygous mice. (J:246524)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ephx3 Mutation: 17 strains or lines available

References

• Original: J:246524 Hoopes SL, et al., Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice. PLoS One. 2017;12(4):e0175348
• All: 2 reference(s)