Hcfc2^sca
Chemically induced Allele Detail

Summary

• Symbol: Hcfc2^sca
• Name: host cell factor C2; scaffold
• MGI ID: MGI:6108106
• Gene: Hcfc2 Location: Chr10:82531994-82578262 bp, + strand Genetic Position: Chr10, 39.93 cM
• Alliance: Hcfc2^sca page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A point mutation that results in the amino acid substitution of isoleucine for phenylalanine at position 599 (F599I). (J:251008)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hcfc2 Mutation: 32 strains or lines available

References

• Original: J:251008 Sun L, et al., HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections. J Exp Med. 2017 Nov 06;214(11):3263-3277
• All: 1 reference(s)