Bag3^tm1.1Chen
Targeted Allele Detail

Summary

• Symbol: Bag3^tm1.1Chen
• Name: BCL2-associated athanogene 3; targeted mutation 1.1, Ju Chen
• MGI ID: MGI:6107852
• Synonyms: Bag3^m
• Gene: Bag3 Location: Chr7:128125340-128148705 bp, + strand Genetic Position: Chr7, 70.26 cM
• Alliance: Bag3^tm1.1Chen page

Significant growth retardation in Bag3^tm1.1Chen/Bag3^tm1.1Chen (m/m) mutant mice compared with littermate control

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246352
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Codon 455 GAA encoding glutamic acid in exon 4 was changed to AAA encoding lysine (E455K) and a FRT site flanked neomycin selection cassette was inserted upstream of this mutation. Flp-mediated recombination removed the neomycin cassette. This mutation is equivalent to the human E455K mutation. (J:246352)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bag3 Mutation: 31 strains or lines available

References

• Original: J:246352 Fang X, et al., Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 01;127(8):3189-3200
• All: 1 reference(s)