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Zc3h14tm1d(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Zc3h14tm1d(KOMP)Wtsi
Name: zinc finger CCCH type containing 14; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:6107561
Synonyms: Zc3h14deltaex13
Gene: Zc3h14  Location: Chr12:98746964-98787753 bp, + strand  Genetic Position: Chr12, 49.88 cM, cytoband F1
Mutation
origin
Mutant Cell Line:  EPD0366_5_F01
Germline Transmission:  Earliest citation of germline transmission: J:249492
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 98783160 of Chromosome 12 upstream of exon 13 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 13 at position 98783990. Exon 13 is thus flanked by loxP sites. The lacZ-neo cassette was removed by in vitro flp recombinase expression. Subsequent cre expression cre-mediated recombination removed exon 13, creating a null allele. (J:249492)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zc3h14 Mutation:  7 strains or lines available
References
Original:  J:249492 Rha J, et al., The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice. Hum Mol Genet. 2017 Oct 01;26(19):3663-3681
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory