Ascl1^em1Jesw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ascl1^em1Jesw
• Name: achaete-scute family bHLH transcription factor 1; endonuclease-mediated mutation 1, James Schwob
• MGI ID: MGI:6102944
• Synonyms: Ascl1-TdTomato2, M2A, Mash1-TdTomato2
• Gene: Ascl1 Location: Chr10:87326681-87329522 bp, - strand Genetic Position: Chr10, 43.64 cM
• Alliance: Ascl1^em1Jesw page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: THe mutation is a CRISPR mediated knock-in, inserting two TdTomato open reading frames separated by self-cleaving peptide 2A sequences, enabling expression of individual proteins, TdTomato and Ascl1. (J:250370)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ascl1 Mutation: 28 strains or lines available

References

• Original: J:250370 Lin B, et al., Injury Induces Endogenous Reprogramming and Dedifferentiation of Neuronal Progenitors to Multipotency. Cell Stem Cell. 2017 Dec 7;21(6):761-774.e5
• All: 1 reference(s)