Hdac1^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Hdac1^{tm1c(EUCOMM)Wtsi}
• Name: histone deacetylase 1; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6101465
• Synonyms: Hdac1^Flox
• Gene: Hdac1 Location: Chr4:129409897-129436506 bp, - strand Genetic Position: Chr4, 63.26 cM
• Alliance: Hdac1^{tm1c(EUCOMM)Wtsi} page
• IMPC: Hdac1 gene page

Mutation origin

• Mutant Cell Line: EPD0028_5_G01
• Germline Transmission: Earliest citation of germline transmission: J:249971
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 129422449 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 129423262. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:249971)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac1 Mutation: 38 strains or lines available

References

• Original: J:249971 Milstone ZJ, et al., Histone deacetylase 1 and 2 are essential for murine neural crest proliferation, pharyngeal arch development, and craniofacial morphogenesis. Dev Dyn. 2017 Dec;246(12):1015-1026
• All: 4 reference(s)