Epha4^tm7Kln
Targeted Allele Detail

Summary

• Symbol: Epha4^tm7Kln
• Name: Eph receptor A4; targeted mutation 7, Rudiger Klein
• MGI ID: MGI:6099091
• Synonyms: Epha4^CR
• Gene: Epha4 Location: Chr1:77343822-77491725 bp, - strand Genetic Position: Chr1, 39.55 cM, cytoband C1-C5
• Alliance: Epha4^tm7Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247837
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cleavage resistant (CR) isoform of the receptor is expressed. The endogenous cleavage region was replaced with sequence from the related Epha3 receptor, which is not cleaved in the same manner. (J:247837)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epha4 Mutation: 67 strains or lines available

References

• Original: J:247837 Gatto G, et al., EphA4 receptor shedding regulates spinal motor axon guidance. Curr Biol. 2014 Oct 20;24(20):2355-65
• All: 1 reference(s)