Tg(Myh6-Pparg)HIjg
Transgene Detail

Summary

• Symbol: Tg(Myh6-Pparg)HIjg
• Name: transgene insertion H, Ira J Goldberg
• MGI ID: MGI:6099070
• Synonyms: MHC-PPARgamma1H
• Transgene: Tg(Myh6-Pparg)HIjg Location: unknown
• Alliance: Tg(Myh6-Pparg)HIjg page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Modified isoform(s))
• Mutation: Insertion
• Tg(Myh6-Pparg)HIjg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pparg (MGI:97747)	Gamma1 isoform of Pparg

• Mutation details: The transgene insert comprises the following: 5.4 kb of genomic sequence containing the mouse myosin heavy chain alpha (cardiac) promoter and exons 1-3, a cDNA for the gamma1 isoform of the mouse Pparg gene and poly(A) features. This allele drives overexpression of the inserted gene in the heart, as shown by RT-PCR experiments. This allele is a high expressing allele. (J:127393)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127393 Son NH, et al., Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice. J Clin Invest. 2007 Oct;117(10):2791-801
• All: 1 reference(s)