Sphk1^tm1Geno
Targeted Allele Detail

Summary

• Symbol: Sphk1^tm1Geno
• Name: sphingosine kinase 1; targeted mutation 1, Genoway
• MGI ID: MGI:6095627
• Gene: Sphk1 Location: Chr11:116421751-116427501 bp, + strand Genetic Position: Chr11, 81.42 cM, cytoband E2
• Alliance: Sphk1^tm1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248572
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exons 3 through 6. (J:248572)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sphk1 Mutation: 29 strains or lines available

Notes

Originally published in Pushparaj PN et al. "Sphingosine kinase1 is pivotal for Fc{epsilon}RI-mediated mast cell signaling and functional responses in vitro and in vivo" (J Immunol. 2012 Sep 15;189(6):3262) but later retracted (see retraction PMID: 22956763 for more detail). The retraction did not impact the generation of the alleles performed by Genoway.

References

• Original: J:248572 Genoway, Generation of Sphk1 and Sphk2. 2017
• All: 5 reference(s)