Astn2^tm1.1Nat
Targeted Allele Detail

Summary

• Symbol: Astn2^tm1.1Nat
• Name: astrotactin 2; targeted mutation 1.1, Jeremy Nathans
• MGI ID: MGI:6093709
• Synonyms: Astn2^ex5fl
• Gene: Astn2 Location: Chr4:65299040-66322774 bp, - strand Genetic Position: Chr4, 34.31 cM, cytoband C1
• Alliance: Astn2^tm1.1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228899
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exon 5 and a Frt-Neo-Frt (FNF) positive selection cassette was inserted adjacent to the 3' loxP site. The Neo cassette was removed in mice via Flp-mediated recombination, leaving loxP sites flanking exon 5. (J:228899)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Astn2 Mutation: 62 strains or lines available

References

• Original: J:228899 Chang H, et al., Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles. PLoS Genet. 2015 Sep;11(9):e1005532
• All: 1 reference(s)