Cnr1^tm1.1Xiaz
Targeted Allele Detail

Summary

• Symbol: Cnr1^tm1.1Xiaz
• Name: cannabinoid receptor 1; targeted mutation 1.1, Xia Zhang
• MGI ID: MGI:6093694
• Synonyms: CB1R-floxed
• Gene: Cnr1 Location: Chr4:33924593-33948831 bp, + strand Genetic Position: Chr4, 16.28 cM
• Alliance: Cnr1^tm1.1Xiaz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248352
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1, and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 2. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 2 floxed. (J:248352)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnr1 Mutation: 41 strains or lines available

References

• Original: J:248352 Wang Y, et al., Monoacylglycerol lipase inhibitors produce pro- or antidepressant responses via hippocampal CA1 GABAergic synapses. Mol Psychiatry. 2017 Feb;22(2):215-226
• All: 5 reference(s)