Arrb2^tm1.1Mca
Targeted Allele Detail

Summary

• Symbol: Arrb2^tm1.1Mca
• Name: arrestin, beta 2; targeted mutation 1.1, Marc G Caron
• MGI ID: MGI:5927418
• Synonyms: betaarr2^f
• Gene: Arrb2 Location: Chr11:70323461-70331654 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Arrb2^tm1.1Mca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247440
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J x 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 1. A second loxP site was inserted into intron 2. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 2 floxed. (J:247440)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arrb2 Mutation: 27 strains or lines available

References

• Original: J:247440 Urs NM, et al., Distinct cortical and striatal actions of a beta-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8178-E8186
• All: 7 reference(s)