Dbn1^{Gt(OST7352)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Dbn1^{Gt(OST7352)Lex}
• Name: drebrin 1; gene trap OST7352, Lexicon Genetics
• MGI ID: MGI:5925399
• Gene: Dbn1 Location: Chr13:55621242-55635924 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Dbn1^{Gt(OST7352)Lex} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242810
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector was inserted into intron 8, creating a knockout allele. Western blots confirmed the absence of protein expression from the allele. (J:86696, J:242810)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dbn1 Mutation: 43 strains or lines available

References

• Original: J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
• All: 3 reference(s)