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Gas2l3tm1c(EUCOMM)Hmgu
Targeted Allele Detail
Nomenclature
Symbol: Gas2l3tm1c(EUCOMM)Hmgu
Name: growth arrest-specific 2 like 3; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:5925364
Synonyms: Gas2l3fl
Gene: Gas2l3  Location: Chr10:89408823-89443967 bp, - strand  Genetic Position: Chr10, 44.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:244087
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 89429635 of Chromosome 10 upstream of exon 6 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 6 at position 89428788. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:244087)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gas2l3 Mutation:  20 strains or lines available
References
Original:  J:244087 Stopp S, et al., Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8029-8034
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory