Gt(ROSA)26Sor^{tm1(CAG-Atoh1,-eGFP)Haoz}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Atoh1,-eGFP)Haoz}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Haotian Zhao
• MGI ID: MGI:5925319
• Synonyms: A1G
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Atoh1,-eGFP)Haoz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243119
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A construct comprising the following elements was inserted into the host locus: CAG promoter, a loxP site, a neomycin resistance gene cassette, a STOP cassette, a loxP site, the mouse gene with a 3' fusion of sequence coding for a hemagglutinin (HA) tag, an FRT site, IRES sequence, the eGFP fluorescent reporter gene, an FRT site, and poly(A) features. The inserted mouse gene and the reporter gene will only be expressed after removal of the neo-STOP cassette through cre-mediated recombination. The reporter gene can be removed through flp-mediated recombination. (J:243119)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 945 strains or lines available

References

• Original: J:243119 Grausam KB, et al., ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas. Cancer Res. 2017 Jul 15;77(14):3766-3777
• All: 1 reference(s)