Gt(ROSA)26Sor^{tm1(CAG-Pgr)Fjd}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Pgr)Fjd}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Franco J DeMayo
• MGI ID: MGI:5925289
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Pgr)Fjd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243133
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A construct comprising the following elements was inserted into the host locus: CAG promoter, loxP site flanked STOP cassette, transcription start site, sequence for FLAG and Myc epitope tags, cDNA for the A isoform of the mouse progesterone receptor gene Pgr, and poly(A) features. This creates a conditional-ready allele where the inserted gene is only expressed after removal of the STOP cassette through cre-mediated recombination. (J:243133)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

References

• Original: J:243133 Wetendorf M, et al., Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment. Biol Reprod. 2017 Feb 01;96(2):313-326
• All: 4 reference(s)