Pjvk^tm1.1Masch
Targeted Allele Detail

Summary

• Symbol: Pjvk^tm1.1Masch
• Name: pejvakin; targeted mutation 1.1, Martin Schwander
• MGI ID: MGI:5925280
• Synonyms: Pjvk^fl
• Gene: Pjvk Location: Chr2:76480617-76488898 bp, + strand Genetic Position: Chr2, 45.08 cM
• Alliance: Pjvk^tm1.1Masch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240546
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a second loxP site in intron 1. An FRT site flanked neomycin resistance gene cassette was inserted into intron 1. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with a floxed exon 1. (J:240546)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pjvk Mutation: 19 strains or lines available

References

• Original: J:240546 Kazmierczak M, et al., Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner. J Neurosci. 2017 Mar 29;37(13):3447-3464
• All: 2 reference(s)