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Mrgprdtm1.1(cre/ERT2)Wql
Targeted Allele Detail
Nomenclature
Symbol: Mrgprdtm1.1(cre/ERT2)Wql
Name: MAS-related GPR, member D; targeted mutation 1.1, Wenqin Luo
MGI ID: MGI:5924939
Gene: Mrgprd  Location: Chr7:145314835-145324059 bp, + strand  Genetic Position: Chr7, 89.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:245897
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    Tamoxifen
Mutation:    Undefined
 
Mutation detailsA targeting construct was designed to insert a creERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain) followed by a frt-flanked neomycin resistance (neo) cassette, just downstream of the start codon of the MAS-related GPR, member D (Mrgprd) gene. Breeding to B6.129S4-Gt(ROSA)26Sor/J (Stock No. 007844) removed the neo cassette. (J:245897)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mrgprd     Summary of all recombinase alleles driven by Mrgprd.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mrgprd Mutation:  12 strains or lines available
References
Original:  J:245897 Olson W, et al., Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors. Elife. 2017 Oct 12;6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory