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Transgene Detail
Symbol: Tg(tetO-TARDBP*A315T)13Lmit
Name: transgene insertion 13, Lars M Ittner
MGI ID: MGI:5922010
Transgene: Tg(tetO-TARDBP*A315T)13Lmit  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(tetO-TARDBP*A315T)13Lmit expresses 1 gene
Mutation detailsThe human cDNA was engineered with a c.1077G>A point mutation, resulting in codon 315 changing from alanine to threonine (p.A315T or p.Ala315Thr). This mutation is associated with familial amyotrophic lateral sclerosis (ALS) in humans. A construct comprising the tetracycline inducible tetO promoter, the human cDNA and an SV40 poly signal, was injected into the pronuclei of fertilized C57BL/6 oocytes. Two lines, this line and numbers 6, were selected for further study. (J:245760)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:245760 Ke YD, et al., Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS. Acta Neuropathol. 2015 Nov;130(5):661-78
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory